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Inside a new review, we reported the identification and the characterization of a whole new atypical opioid receptor with one of a kind destructive regulatory properties toward opioid peptides.1 Our success confirmed that ACKR3/CXCR7, hitherto generally known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is likewise a wide-spe